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Differential Hematotoxic Activity of Southeast Asian Pit Viper Venoms: The Cross-Neutralizing Effect of Available Antivenoms

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  Image Credit: Creative Commons (some rights reserved) CC BY-NC Photo 111998430, (c) Nicholas Hess Differential Hematotoxic Activity of Southeast Asian Pit Viper Venoms: The Cross-Neutralizing Effect of Available Antivenoms Abstract Background/Objectives : Pit vipers (subfamily Crotalinae) are responsible for a large proportion of snakebite envenoming cases in Southeast Asia. Envenomation by these snakes commonly causes hematotoxic effects, including platelet dysfunction and coagulation disturbances. Although antivenom remains the mainstay of treatment, species-specific antivenoms are not available for several regional pit viper species. This study evaluated the hematotoxic activities of selected Southeast Asian pit viper venoms and the cross-neutralizing capacity of commercially available antivenoms.  Methods : Venoms from five medically important pit viper species— Calloselasma rhodostoma ,  Trimeresurus albolabris ,  T. hageni ,  T. purpureomaculatus , ...

Additions to the spider fauna (Araneae) of Algeria: first records of five species from the northern Sahara

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A new endemic genus of tarantula (Theraphosidae, Ischnocolinae) from southern Peru

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Testing the Limits of Morphology: A Comprehensive Morphometric Study of the Sister Lineages Lasiocyano Galleti-Lima, Hamilton, Borges and Guadanucci, 2023 and Lasiodora C. L. Koch, 1850 (Theraphosidae, Mygalomorphae)

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Taxonomic review of the North American species of the accentuata and celer groups of the genus Anyphaena Sundevall, 1833 (Araneae: Anyphaenidae), with description of eight new species

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Big Spider, Big Genome: Chromosome-level genome of a North American tarantula (Aphonopelma marxi) and comparative genomics across 300 million years of spider evolution

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The action of marimastat, a metalloprotease inhibitor, on the coagulant, hemorrhagic, and neuromuscular activities of Lachesis muta (South American bushmaster) venom

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Snakebite epidemiology in the State of Mexico, Mexico 2003-2024

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Three new species of the segmented spider genus Songthela (Araneae: Mesothelae: Liphistiidae) from Guizhou, China

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Spider peptides from Brachypelma smithi with slightly different amino acids at their C-terminal loops exert different insecticidal activities

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Humanized synthetic nanobody library for antivenom development

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A cross-sectional study of scorpion stings in high-risk areas of Islamic Republic of Iran

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Inhibition of Chikungunya virus nsP2 protease in vitro by scorpion venom peptide pantinin-1

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Electrophysiological Characterization of the Venom and Toxins from the Scorpion Tityus championi Targeting Voltage-Gated Sodium Channels and Molecular Modeling of Tch3, a Toxin with Therapeutic Potential for Pain Relief

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Cyanidin-3-O-glucoside (C3G): A natural small-molecule compound for alleviating envenomation symptoms Induced by Bungarus multicinctus

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A proactive multidisciplinary approach to Naja atra envenomation reduces surgical burden and length of hospital stay

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Pre-cheliceral region patterning in a spider provides new insights into the development and evolution of arthropod neurosecretory centres

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Spider Web Architecture and Rainfall Damage: Observational and Manipulative Studies Along a Precipitation Gradient on the Tropical Andes

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Comparison of two populations of the scorpion Centruroides mascota: venom composition and neutralization by a human recombinant antibody

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Biofactories Applied to Future Antivenom Production

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