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The underlying mechanism of scorpion venom peptide BmK AS in reducing epilepsy seizures: mediated through dual modulation of Nav1.6 and the inflammasome pathway

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  The underlying mechanism of scorpion venom peptide BmK AS in reducing epilepsy seizures: mediated through dual modulation of Nav1.6 and the inflammasome pathway Abstract Introduction:  Voltage-gated sodium channel (VGSC) dysregulation, particularly of the Nav1.6 subtype, is a core mechanism underlying epileptogenesis and its associated neuropsychiatric comorbidities. The scorpion venom peptide BmK AS has demonstrated anticonvulsant potential, but its efficacy in chronic epilepsy and the precise mechanisms of action remain undefined. Methods:  Here, we show that BmK AS exerts robust anti-epileptic and neuroprotective effects through converging mechanisms. In a kainic acid-induced mouse model, BmK AS treatment reduced mortality and seizure parameters. Electrophysiological studies assessed BmK AS modulation of VGSC subtypes. The functional relevance of Nav1.6 targeting was confirmed by the loss of BmK AS’s anti-seizure efficacy upon its pharmacological blockade in a PTZ-in...

Cloning and functional analysis of vitellogenin receptor gene PastVgR1 regulates reproduction in Pardosa astrigera (Araneae: Lycosidae): a potential target for mass rearing of predatory spiders in pest management

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Differential Hematotoxic Activity of Southeast Asian Pit Viper Venoms: The Cross-Neutralizing Effect of Available Antivenoms

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Additions to the spider fauna (Araneae) of Algeria: first records of five species from the northern Sahara

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A new endemic genus of tarantula (Theraphosidae, Ischnocolinae) from southern Peru

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Testing the Limits of Morphology: A Comprehensive Morphometric Study of the Sister Lineages Lasiocyano Galleti-Lima, Hamilton, Borges and Guadanucci, 2023 and Lasiodora C. L. Koch, 1850 (Theraphosidae, Mygalomorphae)

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Taxonomic review of the North American species of the accentuata and celer groups of the genus Anyphaena Sundevall, 1833 (Araneae: Anyphaenidae), with description of eight new species

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Big Spider, Big Genome: Chromosome-level genome of a North American tarantula (Aphonopelma marxi) and comparative genomics across 300 million years of spider evolution

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The action of marimastat, a metalloprotease inhibitor, on the coagulant, hemorrhagic, and neuromuscular activities of Lachesis muta (South American bushmaster) venom

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Snakebite epidemiology in the State of Mexico, Mexico 2003-2024

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Three new species of the segmented spider genus Songthela (Araneae: Mesothelae: Liphistiidae) from Guizhou, China

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Spider peptides from Brachypelma smithi with slightly different amino acids at their C-terminal loops exert different insecticidal activities

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Humanized synthetic nanobody library for antivenom development

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A cross-sectional study of scorpion stings in high-risk areas of Islamic Republic of Iran

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Inhibition of Chikungunya virus nsP2 protease in vitro by scorpion venom peptide pantinin-1

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Electrophysiological Characterization of the Venom and Toxins from the Scorpion Tityus championi Targeting Voltage-Gated Sodium Channels and Molecular Modeling of Tch3, a Toxin with Therapeutic Potential for Pain Relief

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Cyanidin-3-O-glucoside (C3G): A natural small-molecule compound for alleviating envenomation symptoms Induced by Bungarus multicinctus

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A proactive multidisciplinary approach to Naja atra envenomation reduces surgical burden and length of hospital stay

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Pre-cheliceral region patterning in a spider provides new insights into the development and evolution of arthropod neurosecretory centres

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Spider Web Architecture and Rainfall Damage: Observational and Manipulative Studies Along a Precipitation Gradient on the Tropical Andes

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