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Investigating the therapeutic role of Leuculectin, a C-type lectin from Bothrops leucurus snake venom, in corneal neovascularization

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  Investigating the therapeutic role of Leuculectin, a C-type lectin from Bothrops leucurus snake venom, in corneal neovascularization Abstract Pathological corneal neovascularization remains a major therapeutic challenge due to the limited efficacy and safety of currently available antiangiogenic treatments. Although C-type lectins from snake venom possess various biological activities, their potential to modulate pathological ocular angiogenesis has not been explored. This study investigated the antiangiogenic effects of Leuculectin, a C-type lectin isolated from Bothrops leucurus venom using an experimental model of corneal neovascularization (CNV), a HUVEC (human umbilical vein endothelial cell) tube formation assay, and the chick embryo chorioallantoic membrane (CAM) assay. In the HUVEC tube formation assay, Leuculectin demonstrated strong antiangiogenic activity. In the CAM assay, Leuculectin applied at concentrations of 1.5, 2.5 and 3.5 μg/mL significantly decreased new ves...

New species and records of spiders (Arachnida: Araneae) from the Maghreb

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Antivenom efficacy and Traditional Practices for Snakebite in Brazil: Where Do They Meet?

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Envenomization with Snake Versus Scorpion Venom: Postmortem Repercussions on the Successional Dynamics of Carcass-Attracted Flies in a Forensic Context

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Functional and Taxonomic Structuring of Ground-Dwelling Spider Communities Under the Combined Effects of the Environment and Metal Contamination

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Cicileus derradji sp. nov., a new species from southern Algeria (Scorpiones: Buthidae)

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Alpiscorpius kaleensis sp. nov., a new scorpion species from Denizli Province, Turkey (Scorpiones: Euscorpiidae)

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Untangling the coxa-trochanter joint appendotomy in spiders (Arachnida: Araneae)

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