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Big Spider, Big Genome: Chromosome-level genome of a North American tarantula (Aphonopelma marxi) and comparative genomics across 300 million years of spider evolution

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  Image Credit: WikiCommons Big Spider, Big Genome: Chromosome-level genome of a North American tarantula (Aphonopelma marxi) and comparative genomics across 300 million years of spider evolution Abstract The comparison of chromosome-level genomes allows biologists to investigate new axes of organismal evolution. Spiders comprise a significant proportion of known arachnid diversity, with many complex morphologies and unique natural histories, yet comparative genomics in spiders has been limited due to the number of available genomes. We present a de novo chromosomal reference genome of a mature male tarantula, Aphonopelma marxi, and comparatively examine spider genome evolution across the Order Araneae. Using PacBio HiFi and Hi-C sequencing, the final 6.5 Gb assembly consists of 17 autosomes, 1 X chromosome, and 127 unplaced scaffolds, with an N50 of 370 Mb and Arachnida (odb10; 2934 genes) BUSCO of 96.7%. By comparing 20 additional spider genomes from 15 families, we find mygalomo...

The action of marimastat, a metalloprotease inhibitor, on the coagulant, hemorrhagic, and neuromuscular activities of Lachesis muta (South American bushmaster) venom

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Snakebite epidemiology in the State of Mexico, Mexico 2003-2024

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Three new species of the segmented spider genus Songthela (Araneae: Mesothelae: Liphistiidae) from Guizhou, China

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Spider peptides from Brachypelma smithi with slightly different amino acids at their C-terminal loops exert different insecticidal activities

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Humanized synthetic nanobody library for antivenom development

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A cross-sectional study of scorpion stings in high-risk areas of Islamic Republic of Iran

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Inhibition of Chikungunya virus nsP2 protease in vitro by scorpion venom peptide pantinin-1

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Electrophysiological Characterization of the Venom and Toxins from the Scorpion Tityus championi Targeting Voltage-Gated Sodium Channels and Molecular Modeling of Tch3, a Toxin with Therapeutic Potential for Pain Relief

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Cyanidin-3-O-glucoside (C3G): A natural small-molecule compound for alleviating envenomation symptoms Induced by Bungarus multicinctus

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A proactive multidisciplinary approach to Naja atra envenomation reduces surgical burden and length of hospital stay

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Pre-cheliceral region patterning in a spider provides new insights into the development and evolution of arthropod neurosecretory centres

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Spider Web Architecture and Rainfall Damage: Observational and Manipulative Studies Along a Precipitation Gradient on the Tropical Andes

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Comparison of two populations of the scorpion Centruroides mascota: venom composition and neutralization by a human recombinant antibody

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Biofactories Applied to Future Antivenom Production

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Pediatric Scorpion Envenomation in Tunisia: Epidemiology, Clinical Features, Therapeutic Management and Outcomes in a 14-Year Cohort Study

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Microhabitat Preference of Coremiocnemis cunicularia and Chilobrachys andersoni in Pulau Pinang, Malaysia

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Large animal models for the assessment of snakebite envenoming therapies

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Crystal structure and functional characterization of an Asp49 phospholipase A2 from the bushmaster (Lachesis muta)

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An eyeless new species of Monoblemma Gertsch, 1941 (Araneae: Tetrablemmidae) from Venezuela, with a new record of the single-eyed Monoblemma unicum Gertsch, 1941 from the Dominican Republic

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