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Venom gland transcriptomics and bioactivity profiling suggest bifunctional hyaluronidase activity in the venom of Mesobuthus crucittii (Scorpiones: Buthidae)

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  Venom gland transcriptomics and bioactivity profiling suggest bifunctional hyaluronidase activity in the venom of Mesobuthus crucittii (Scorpiones: Buthidae) Abstract Introduction: Scorpion venom is a rich source of bioactive molecules with promising biomedical applications. Hyaluronidases are venom-associated enzymes that facilitate toxin diffusion by degrading extracellular matrix glycosaminoglycans, yet their structural diversity and substrate specificity in scorpion venoms remain insufficiently explored. This study aimed to identify and characterize a novel hyaluronidase from the venom gland of the Iranian endemic scorpion Mesobuthus crucittii and evaluate its biochemical and structural properties. Methods: Venom gland transcriptome profiling was performed. Hyaluronidase sequences were analyzed in silico via phylogenetic reconstruction, motif prediction, physicochemical property calculation, and structural modeling. Molecular docking was conducted to explore interactions wi...

Ontogenetic and geographic venom variation in the Great Basin Rattlesnake, Crotalus oreganus lutosus

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Urban Spider Assemblages in a Neotropical City: Diversity, Functional Composition, and Introduced Species in Public Parks of Chetumal, Mexico

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A new species of Strotarchus Simon, 1888 from Mexico and description of the male of the type species S. nebulosus Simon, 1888 (Araneae: Cheiracanthiidae)

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A review of Idiommata Ausserer, 1871 (Mygalomorphae: Barychelidae), with the description of a related new genus and new species of giant Australian brush-footed spiders

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Compsobuthus hadeki sp. n. from Iraq (Scorpiones: Buthidae)

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Egg-Carrying and Cheliceral Comb in Ibaloniinae Harvestmen From the Solomon Islands (Opiliones: Podoctidae)

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Huntsman spiders of the genus Sinopoda (Araneae, Sparassidae, Heteropodinae) from the Honghe Hani and Yi Autonomous Prefecture, southwestern China, with descriptions of two new species

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Multidimensional toxicity of snake venom causes multi-organ damage and treatment challenges: a narrative review

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A new Nemesia species from Spanish Catalonia (Araneae, Mygalomorphae, Nemesiidae, Haplonemesia)

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Mechanism of Anticoagulation, Inhibition of In Vivo Thrombus Formation, and Assessment of Preclinical Safety of a Snake Venom Phospholipase A2 Enzyme-inspired New Antithrombotic Custom Peptide

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First fossil of the pseudoscorpion family Chernetidae Menge, 1855 (Arachnida, Pseudoscorpiones) from mid-Cretaceous Burmese amber

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Beyond morphology alone: species delimitation, hemispermatophore comparisons and comments on the systematic status of Scorpiops Peters, 1861 (Scorpiones: Scorpiopidae) with a description of three new species from peninsular India

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Venom Variation as a Window into the Ecology and Evolution of Snakes

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Passing of Petra Sierwald

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ECOLOGICAL NICHE MODELS BY TITYUS SERRULATUS LUTZ & MELLO, 1922 AND TITYUS STIGMURUS (THORELL, 1876) (ARACHNIDA: SCORPIONES)

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Two New Troglobitic Species of Giupponia Pérez-González & Kury, 2002 (Opiliones: Gonyleptoidea) from Caves of Bahia, Northeastern Brazil

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A Structure-Informed Atlas of Venom-Derived Peptides Reveals the Organization of Chemical Space

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Transcriptomic Insights Into the Evolution of Snake Venom: Mechanisms, Diversity, and Adaptation

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Suitable habitats for Ebrechtella tricuspidata (Araneae, Thomisidae) in China under climate change: implications for biological control

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