Exploring the Inter- and Intra-Specific Variability of Androctonus Scorpion Venoms

 

Exploring the Inter- and Intra-Specific Variability of Androctonus Scorpion Venoms 

Abstract

Scorpion venom possesses a lethal sting and potential medicinal properties, making it a captivating natural elixir. Our study aimed to unravel the composition of Androctonus scorpion venoms in Morocco. Using electrospray mass spectrometry and high-performance liquid chromatography (HPLC), we conducted a thorough analysis to gain detailed insights into venom composition. The data unveiled a wide range of molecular weights, influenced by factors such as species, genus, location, age, sex, and diet. Short toxins (2000–4000 Da) predominated in the venoms, effectively blocking K+ channels, while larger molecular weights (>4000 Da) corresponded to long toxins that modulate Na+ channels. Furthermore, we made intriguing discoveries of previously unidentified peptides (<2000 Da). This study provides valuable knowledge, shedding light on the intricate composition of scorpion venoms.

Hilal, Ines, Soukaina Khourcha, Amal Safi, Abdelaziz Hmyene, Reto Stöcklin, and Naoual Oukkache. 2023. "Exploring the Inter- and Intra-Specific Variability of Androctonus Scorpion Venoms" Biology and Life Sciences Forum 24, no. 1: 12. https://doi.org/10.3390/IECT2023-14797