AaTs-1, a Tetrapeptide from Scorpion Venom Mitigates Demyelination and Neuroinflammation in a Cuprizone-Induced Model of Multiple Sclerosis

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  AaTs-1, a Tetrapeptide from Scorpion Venom Mitigates Demyelination and Neuroinflammation in a Cuprizone-Induced Model of Multiple Sclerosis Abstract Purpose This study focuses on the evaluation of the therapeutic potential of Tetrascorpin-1 (AaTs-1), a tetrapeptide isolated from Androctonus australis hector venom, proposed as a putative formyl peptide receptor 2 (FPR2) antagonist, in a cuprizone-induced murine model of Multiple sclerosis (MS), a chronic autoimmune and inflammatory disease of the central nervous system. Methods Acute demyelination was induced in mice by administering cuprizone (0.2% w/w in the diet) for six weeks. During the sixth week of cuprizone intake, demyelinated mice received intranasal administration of AaTs-1 at a dose of 50–100 µg/kg for five consecutive days, with 24-hour intervals between treatments. Results Behavioral assessments, immunological assays, and histological analyses revealed that AaTs-1 improved body weight, reduced behavioral impairments...

On the identity of Pardosa consimilis Nosek, 1905 with a first description of the male and notes on two related species (Araneae: Lycosidae)

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On the identity of Pardosa consimilis Nosek, 1905 with a first description of the male and notes on two related species (Araneae: Lycosidae)

Abstract 


More than a hundred years after its description in 1905, the wolf spider Pardosa consimilis Nosek, 1905 was known solely from the original description of a single female, the holotype. In the last decade there were reports of the species from Bulgaria. Several reports followed with possible records of the yet-unknown males but they were not described; these came from four countries at least: North Macedonia, Georgia, Albania and most recently from Iran. Pardosa consimilis belongs to the monticola group and can be assigned to separate albatula-complex. The aim of this article is to provide a description for the male of Pardosa consimilis for the first time and to redescribe the female, in comparison with its closest congeners P. albatula (Roewer, 1951) and P. blanda (C. L. Koch, 1833).

Naumova, M. & Deltshev, C. (2023). On the identity of Pardosa consimilis Nosek, 1905 with a first description of the male and notes on two related species (Araneae: Lycosidae). Zootaxa 5352(4): 553-564. doi:10.11646/zootaxa.5352.4.6