Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides

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  Molecular Recognition and Immunopharmacological Implications of Serratiopeptidase Targeting Snake Venom Bradykinin-Potentiating Peptides Abstract Purpose Bradykinin-potentiating peptides (BPPs), found in snake venom, are known to modulate cardiovascular functions, but their susceptibility to enzymatic degradation remains poorly understood. Methods Models were generated using AlphaFold-Colab for five small BPPs (< 9 amino acids) that did not have experimentally solved structures, and those BPPs which had reliable predictions of structure (pLDDT > 80) were used for docking studies. Protein-peptide docking experiments were done using HADDOCK for studying the interaction between wild-type (WT) and mutant serratiopeptidase with BPPs. After selecting the best complex, simulation of the complex was done using molecular dynamics (MD) simulations for 100 ns and binding energy determination using MM/PBSA analysis. For checking the mechanical stability of the protein-peptide complexes...

Checklist of Fauna of India: Scorpiones, Uropygi, Pseudoscorpiones, Amblypygi and Palpigradi

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Checklist of Fauna of India: Scorpiones, Uropygi, Pseudoscorpiones, Amblypygi and Palpigradi

The Zoological Survey of India (ZSI) was established on 1st July, 1916 to promote survey, exploration and research leading to the advancement in our knowledge of various aspects of exceptionally rich life of the erstwhile ´British Indian Empire´. The survey has its genesis in the establishment of the Zoological Section of the Indian Museum at Calcutta in 1875. By gradually strengthening its staff and expanding its research programme, the Survey has met the challenge of the past and is on its way to meet the demands of the future. It has maintained its primary objectives unchanged from its inception.

Ghosh, A., Sen, S. (2024). Fauna of India Checklist: Version 1.0. Zoological Survey India.