Broad-Scale Climatic Gradients Drive Multiple Facets of Scorpion Beta Diversity in Northeastern Brazil

Posted by
  Broad-Scale Climatic Gradients Drive Multiple Facets of Scorpion Beta Diversity in Northeastern Brazil ABSTRACT Aim Beta diversity analyses clarify mechanisms structuring ecological communities, but their multidimensional facets remain poorly explored in arthropods. Here, we quantified taxonomic, phylogenetic, and functional beta diversity in scorpions, partitioned these facets into species replacement and richness differences, and evaluated the relative importance of spatial structure and environmental conditions in driving community assembly. Location Northeastern Brazil, South America. Taxon Scorpions (Arachnida: Scorpiones). Methods Taxonomic beta diversity was estimated using species presence across 70 sites in northeastern Brazil. Phylogenetic turnover was calculated from a multi-locus molecular tree, and functional beta diversity was derived from morphometric and ecological traits. All beta diversity facets were decomposed into replacement and richness-difference component...

A review on inflammation modulating venom proteins/peptide therapeutics and their delivery strategies: A review

Posted by

 


A review on inflammation modulating venom proteins/peptide therapeutics and their delivery strategies: A review

Abstract

Inflammation is an initial biological reaction that occurs in response to infection caused by foreign pathogens or injury. This process involves a tightly controlled series of signaling events at the molecular and cellular levels, with the ultimate goal of restoring tissue balance and protecting against invading pathogens. Malfunction in the process of inflammation can result in a diverse array of diseases, such as cardiovascular, neurological, and autoimmune disorders. Therefore, the management of inflammation is of utmost importance in modern medicine. Nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids have long been the mainstays of pharmacological treatment for inflammation, effectively alleviating symptoms in many patients. Recently, toxins and venom, formerly seen as mostly harmful to the human body, have been recognized as possible medicinal substances for treating inflammation. Organisms that are venomous, such as spiders, scorpions, snakes, and certain marine species, have developed a wide range of powerful toxins that can effectively disable or discourage predators. Remarkably, the majority of these poisons and venoms consist of proteins and peptides, which are acknowledged as significant bioactive compounds with medicinal potential. The goal of this review is to investigate the medicinal potential of peptides derived from venoms and their complex mechanism of action in suppressing inflammation. This review also discusses various challenges and future prospects for effective venom delivery.

Hemajha, L., Singh, S., Biji, C. A., Balde, A., Benjakul, S., & Nazeer, R. A. (2024). A review on inflammation modulating venom proteins/peptide therapeutics and their delivery strategies: A review. International Immunopharmacology, 142, 113130. https://doi.org/10.1016/j.intimp.2024.113130