Could venom-derived therapeutics resolve treatment resistance in refractory EAC?

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  Could venom-derived therapeutics resolve treatment resistance in refractory EAC? Abstract The incidence of esophageal adenocarcinoma is rising in Western countries. Despite advances in chemotherapy and immunotherapy, the prognosis remains poor, with an overall 5-year survival rate below 15%. A major challenge is the cancer’s poor and often unpredictable response to current treatments. Animal venoms represent a promising yet underexplored source of therapeutic agents, offering millions of structurally diverse and highly potent bioactive peptides that can modulate a wide array of molecular targets. However, only a small fraction of these peptides has been pharmacologically characterized. This review presents the therapeutic potential of venom-derived peptides in cancer treatment, summarizes the role of ion channels in esophageal adenocarcinoma (EAC), and discusses peptides targeting ion channels that may offer new opportunities for future EAC treatment. Freuville L, Matthys C, Gill...

Additions to the list of scorpions (Arachnida: Scorpiones) intercepted as stowaways in the United Kingdom

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Additions to the list of scorpions (Arachnida: Scorpiones) intercepted as stowaways in the United Kingdom

Abstract
Sherwood & Armas (2023) provided a comprehensive and up to-date list of scorpions detected as stowaways in the United Kingdom. Since that work, the senior author has received further enquiries which contribute a number of new records for the literature. Furthermore, it came to our attention through correspondence with colleagues that we ought to examine the press media for examples of further cases, although these of course are not part of the scientific literature and have not passed peer-review. Nonetheless, we have evaluated these records and found a number with photographs and other information which allow us to provide a family or genus-level identification, at the very least, and in some cases even a species-level identification. 

Sherwood, Danniella & De Armas, Luis & Tchilinguirian, Julien. (2024). Additions to the list of scorpions (Arachnida: Scorpiones) intercepted as stowaways in the United Kingdom. 161. 3-5.