The genus Thrixopelma Schmidt, 1994 from Peru: redescription of the male of T. ockerti Schmidt,1994 (Araneae: Theraphosidae: Theraphosinae), and a new species

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Seven New Guanidine Derivatives and One New Hypoxanthine Derivative Isolated from the Scorpion Buthus martensii and Potential Anti-Neuroinflammatory Activity

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Seven New Guanidine Derivatives and One New Hypoxanthine Derivative Isolated from the Scorpion Buthus martensii and Potential Anti-Neuroinflammatory Activity

Abstract

Twelve guanidine derivatives (1–12), including seven new compounds (martensiiagms A–G, 1–7), one new hypoxanthine derivative (martensiiagm H, 13), and 15 known compounds (14–28) were isolated from the whole body of Buthus martensii Karsch and identified by analysis of data. Subsequent biological evaluations revealed the anti-inflammatory activity of compound 1. It attenuates the neuroinflammation and oxidative stress levels prompted by lipopolysaccharide. This attenuation is accomplished by a specific action on mitochondria, which, in turn, caused a significant decrease in reactive oxygen species and pro-inflammatory cytokines.

Seven New Guanidine Derivatives and One New Hypoxanthine Derivative Isolated from the Scorpion Buthus martensii and Potential Anti-Neuroinflammatory Activity
Ke-Ming Li, Wei-Fen Li, Yong-Ming Yan, Guangyi Yang, and Yong-Xian Cheng
Journal of Natural Products Article ASAP